:root{color-scheme:light;--ink:#132f43;--muted:#526777;--teal:#126f70;--line:#d6e0e7;--paper:#fff;--back:#f4f7fa;--serif:Georgia,'Times New Roman',serif;font:16px/1.55 -apple-system,BlinkMacSystemFont,'Segoe UI',sans-serif;color:var(--ink);background:var(--back)}*{box-sizing:border-box}body{margin:0}button,input{font:inherit}button,a,input{touch-action:manipulation}button{cursor:pointer}a{color:var(--teal)}:focus-visible{outline:3px solid #b07416;outline-offset:4px}button:disabled{opacity:.5;cursor:default}.skip{position:absolute;top:-80px;left:20px;padding:12px;background:white;z-index:20}.skip:focus{top:10px}.masthead{background:var(--ink);color:white;border-bottom:4px solid var(--teal)}.mast-inner{max-width:1400px;margin:auto;padding:24px 40px;display:flex;align-items:center;justify-content:space-between;gap:20px}.brand{display:flex;align-items:center;gap:15px;color:white;text-decoration:none;font:27px var(--serif)}.monogram{display:grid;place-items:center;width:38px;height:43px;border:1px solid #71929f;font-size:31px}.demo-label{font-size:14px;letter-spacing:.06em;border:1px solid #547583;padding:5px 12px;border-radius:3px}.workspace{display:grid;grid-template-columns:280px minmax(0,1fr);gap:48px;max-width:1400px;margin:0 auto;padding:40px}.filters{align-self:start;background:white;border:1px solid var(--line);border-radius:5px;padding:22px;position:sticky;top:24px}.filter-top{display:flex;align-items:center;justify-content:space-between;gap:12px;padding-bottom:18px;border-bottom:1px solid var(--line)}h2{font-size:18px;margin:0}.text-button{border:0;background:none;color:var(--teal);font-size:14px;text-decoration:underline;text-underline-offset:3px;padding:4px 0}.filters fieldset{padding:20px 0 18px;margin:0;border:0;border-bottom:1px solid var(--line);min-width:0}.filters fieldset:last-child{border:0;padding-bottom:0}.filters legend{float:left;width:100%;font-weight:700;font-size:16px;margin-bottom:12px}.filters legend span{font-weight:400;color:var(--muted);margin-left:5px}.filters fieldset>div{clear:both}.check-row{display:flex;align-items:flex-start;gap:10px;position:relative;margin:9px 0;font-size:14px;cursor:pointer}.check-row input{appearance:auto;accent-color:var(--teal);width:17px;height:17px;flex-shrink:0;margin:3px 0 0}.check-row .label{flex:1}.count{min-width:21px;text-align:right;color:var(--muted);font-variant-numeric:tabular-nums}.field-note{font-size:13px;line-height:1.45;color:var(--muted);margin:12px 0 0}.date-label{clear:both;display:block;font-size:14px;margin:12px 0 5px}input[type=date]{width:100%;min-width:0;min-height:42px;border:1px solid #a5b6c1;border-radius:4px;background:white;padding:7px 9px;color:var(--ink);font-size:15px}.undated{margin-top:18px}.error{font-size:14px;color:#992c2c}.eyebrow{font-size:12px;letter-spacing:.15em;font-weight:700;color:var(--teal);margin:0 0 10px}h1{font:normal clamp(30px,3vw,42px)/1.15 var(--serif);margin:0 0 12px;letter-spacing:-.015em}.intro{color:var(--muted);margin:0;font-size:16px}.result-toolbar{display:flex;justify-content:space-between;gap:20px;margin-top:28px;padding:14px 0;border-top:1px solid #bdccd6;border-bottom:1px solid #bdccd6;font-size:14px}.result-toolbar p{margin:0;font-weight:650}.result-toolbar>span{color:var(--muted)}.article-card{padding:28px 0 26px;border-bottom:1px solid #cbd7df;display:grid;grid-template-columns:46px minmax(0,1fr);gap:14px}.article-number{color:#8ba0ae;font:27px/1.2 var(--serif);padding-top:3px}.article-card h2{font:normal 25px/1.3 var(--serif);margin:9px 0 12px}.article-card h2 a{color:var(--ink);text-decoration:none}.article-card h2 a:hover{text-decoration:underline;text-decoration-thickness:1px;text-underline-offset:4px}.article-meta{font-size:14px;color:var(--muted)}.article-meta time{white-space:nowrap}.tag-list{display:flex;gap:7px;flex-wrap:wrap;margin:16px 0}.tag{background:#e5eeef;color:#225a5c;border:1px solid #cfdddd;padding:3px 9px;font-size:12px;font-weight:600;border-radius:3px}.tag.disease{background:white;border-color:#c3d2dd;color:#445d70}.takeaway{margin:0 0 14px;font-size:16px;line-height:1.65;color:#314d60;max-width:76ch}.read-link{font-weight:650;font-size:14px;text-decoration:none;border-bottom:1px solid #7da7a8;padding-bottom:2px}.empty{background:white;border:1px solid var(--line);padding:42px 25px;margin:24px 0}.empty h2{font:26px var(--serif)}.empty p{color:var(--muted)}.empty button{background:var(--ink);color:white;border:0;border-radius:4px;padding:10px 18px}.collection-footnote{color:var(--muted);font-size:13px;margin:24px 0}.loading{padding:30px}dialog{border:0;border-radius:6px;padding:0;width:min(960px,calc(100% - 40px));max-height:92dvh;color:var(--ink);background:white;box-shadow:0 24px 100px #0004}dialog::backdrop{background:rgb(11 30 43 / .65)}.dialog-bar{display:flex;align-items:center;justify-content:space-between;padding:14px 32px;background:var(--ink);color:white;position:sticky;top:0;z-index:1}.dialog-bar>span{font-size:12px;letter-spacing:.12em}.dialog-bar button{border:1px solid #78919e;background:transparent;color:white;padding:6px 12px;border-radius:3px;font-size:14px}.dialog-bar button span{font-size:20px;margin-left:8px;line-height:1}#article-content{padding:35px 44px 42px}#article-title{font:normal 34px/1.2 var(--serif);margin:10px 0 20px;overflow-wrap:anywhere}.citation{font-size:14px;color:var(--muted);margin:0 0 22px}.summary-section{margin:26px 0}.summary-section h3{font-size:17px;color:var(--teal);margin:0 0 9px}.summary-section p{margin:0;line-height:1.75}.summary-section ul{margin:0;padding-left:24px}.summary-section li{margin:10px 0;padding-left:4px;line-height:1.7}.summary-section.final{background:#edf4f5;border-left:3px solid var(--teal);padding:20px 24px}figure{margin:28px 0}figure img{width:100%;height:auto;display:block;border:1px solid var(--line)}figcaption{font-size:13px;color:var(--muted);margin:10px 0}.source-link{display:inline-block;border:1px solid var(--teal);padding:9px 16px;border-radius:3px;text-decoration:none;font-size:14px;font-weight:650}.detail-footer{padding-top:20px;border-top:1px solid var(--line);color:var(--muted);font-size:13px}.no-tag{color:var(--muted);font-size:13px}.dialog-open{overflow:hidden}@media(min-width:1500px){.workspace{gap:60px}}@media(max-width:850px){.workspace{grid-template-columns:230px minmax(0,1fr);gap:26px;padding:26px}.filters{padding:16px}.mast-inner{padding:22px 26px}.article-card{grid-template-columns:1fr;gap:0}.article-number{display:none}.article-card h2{font-size:23px}}@media(max-width:640px){.mast-inner{padding:18px 20px}.brand{font-size:23px}.monogram{display:none}.demo-label{font-size:12px;padding:4px 7px}.workspace{display:flex;flex-direction:column;padding:24px 20px;gap:26px}.filters{position:static;width:100%;order:1}.catalogue{display:contents}.collection-heading{order:0}.result-toolbar{order:2;margin-top:0}.catalogue #results{order:3}.collection-footnote{order:4;margin:0}#filter-form{display:grid;grid-template-columns:1fr 1fr;gap:0 20px}.filters fieldset:last-child{grid-column:1/-1;border-top:1px solid var(--line)}.article-card:first-child{padding-top:0}.article-card h2{font-size:24px}dialog{width:calc(100% - 16px);max-height:96dvh}.dialog-bar{padding:12px 20px}#article-content{padding:24px 22px}#article-title{font-size:28px}.summary-section.final{padding:18px}.date-label{margin-top:9px}}@media(prefers-reduced-motion:no-preference){dialog[open]{animation:appear .16s ease-out}@keyframes appear{from{opacity:0;transform:translateY(8px)}to{opacity:1;transform:translateY(0)}}}